Olympus Labs Elim1nate Revamped to Eliminate Excess Estrogen

For those that concerned with optimizing their androgen levels, such as prohormone users, rising estrogen levels can be a huge issue to overcome. Olympus Labs has addressed this issue with the new version of Elim1nate, a product that works to keep estrogen levels in a healthy range through herbal extracts – one of them new to the land of sports nutrition!

How does the science back it up?

The Premise: Elim1nate Excess Estrogen, Maintain Gains

Olympus Labs, as PricePlow readers know, is one of the most cutting-edge supplement companies around. They adore new ingredients and love pushing the boundaries of products into new territory. Their past of innovation and jaw-dropping formulas has us excited whenever they drop a new product, and Elim1nate is no exception. Olympus Labs designed Elim1nate to provide certain benefits to the consumer, such as:

• Promotion of a lean, dry and hard physique
• Modulation of estrogen levels to increase testosterone levels
• An increase in fat loss and metabolic health
• A push towards healthy levels of insulin sensitivity and plasma cholesterol levels
• Preventing the catabolism of lean muscle tissue.

In order to accomplish these goals, Elm1nate sets out to modulate your estrogen levels with natural ingredients. The formula is a simple two-punch solution to combat rising estrogen levels via newcomer Luteolin and a new twist on Pine Bark Extract, one of our favorite and most underrated ingredients of the last few years.

For those that are constructing a post-cycle therapy stack, Elim1nate is a product designed to fit in the “AI slot” of your stack, but can be used standalone to modulate estrogen for non-hormone users as well, since it doesn’t completely tank estrogen. Before we get into the details, it’s time to check prices and sign up for Olympus Labs news alerts, because this crew has a ton coming:

Elim1nate comes as a capsule-driven product, the most common form of delivery for much of the “anabolic boost” products on the market. While Olympus Labs definitely has some aggressive formulas, we believe this one can easily reach the mainstream. It’s a product designed for any athlete who’s looking to keep estrogen in check – whether or not they’re using more hardcore substances. Now we know what we’re looking at… let’s get to the science.

A Note on Expectations

Please keep in mind that if a product promises to eliminate your estrogen levels entirely, it’s promising to kill you since both males and females need estrogen to live. For a product like this, expect a decent decrease in estrogen levels, not a massive drop that winds up being fatal. In addition, this is a natural herb based product. The effects will not likely resemble a prescription pharmaceutical, nor are they intended to — but only blood tests can determine that.

The Elim1nate Ingredients

• Luteolin as Elimistane (100mg)

  

  Two simple yet science-backed ingredients, to be taken with meals (one capsule per meal, 3-4 total per day)

  Elimistane is a trademarked take on Luteolin, a natural flavonoid that found in a ton of plants, including oranges and artichoke. Recent research has shown that Luteolin may help inhibit aromatase in human cells.[1-4] Aromatase is the enzyme responsible for conversion of testosterone into estrogen in most organisms. By blocking this enzyme, Elim1nate helps lower your estrogen levels while keeping your testosterone high in a single step. Luteolin has a bonus over traditional aromatase inhibitors as well: it’s a broad-spectrum herb!

  Auxiliary benefits of Luteolin

  Beyond just helping you have more testosterone levels, Luteolin can help balance your plasma cholesterol levels. It does so by lowering the amount of low-density lipoproteins (LDL) in circulation while helping create more high-density lipoproteins.[5,6] The take away on lipoproteins is that LDLs are “bad” cholesterol and many cite high levels of LDLs as a part of the pathophysiology of atherosclerosis, although this is hotly contested recently. HDLs, however, are much smaller than LDLs and actively help remove fat deposits from the arteries. Thus, higher plasma levels of HDL help decrease atherosclerosis risk.[7]

  Nootropic benefits and mood enhancement?! Why not!

  

  The concentration−response curve of luteolin inhibition of estrogen biosynthesis in KGN cells

  Since we’re PricePlow, we will touch on the nootropic benefits of Luteolin. Luteolin is an inhibitor of phosphodiesterase-4, an enzyme that reduces cAMP levels.[8] Amongst other things (see the weight loss area below), cAMP is a molecule that helps neurons communicate. By having more cAMP levels, we can improve neuronal communication which boosts focus, optimizes brain function, and improves long-term memory.[9]

  While on that topic, there are often mood-enhancement benefits to ingredients like luteolin as an indirect benefit. This is simply because high estrogen levels can make you feel pretty crappy, to put it nicely. Instead, there’s a bit of an “alpha” confidence to be had when getting your hormones in balance and hitting the gym on the regular.

  Increased cAMP → Increased Energy Expenditure

  

  Let’s be clear – Luteolin is not going to tank your estrogen, but we’re confident it will reduce it to a noticeable and significant degree

  Luteolin may also help with weight loss,[15] since it increases PPAR-gamma in fat cells,[16] leading to increased adiponectin and leptin expression. Adiponectin a protein hormone involved in regulating glucose levels and fatty acid breakdown, while leptin is referred to as “the hormone of energy expenditure”. As mentioned above, luteolin increases cAMP by reducing its inhibitor. A boost in cAMP promotes the oxidation of fatty acids, increases the body’s basal metabolic rate, and increases testosterone.

  So that brings us to our final point, that luteolin may help you stay anabolic. On top of a potential testosterone boost from a cAMP boost, research shows that luteolin can help inhibit atrogin-1 protein, which can help your fight against muscular atrophy.[10]

  To sum it up, luteolin is an herb we don‘t see too often, which tells you how innovative Olympus Labs can be. As it stands, it looks like a promising way to kill two birds with one stone.

• Pine Bark – Standardized from 95% Proanthocyanidins (25mg)

  

  The proposed Olympus Labs Elim1nate Benefits. Chances are, you’re here for the third one!

  It’s hard for Pine Bark to live up to the massive shadow Luteolin casts. Informed PricePlow fans may scratch their heads as pine bark extract is usually used as a blood-flow enhancer in the supplement industry due to its action on nitric oxide levels in the blood.[11] A great benefit that we’ll take any time (especially if it can increase the nutrient delivery of luteolin), but it goes further.

  The real reason it’s here is that an appropriately-extracted pine bark contains flavonoids and resins that may help inhibit aromatase.[12] This action works through the blocking of NF-Kappa.B activity, which “indirectly suppresses inflammation through the reduction of NF-Kappa.b translation of inflammatory genes after its binding to DNA”, eg. primarily through inhibiting the Aromatase enzyme.

  In addition, Pine may help with symptoms of metabolic disease through improved weight loss, glucose regulation, and insulin sensitivity.[13] Finally, pine bark is a wonderful antioxidant.[14]

  Keep in mind that improved blood-flow is man-boosting in its own way, if you catch our drift!

Elim1nate Dosage Instructions

Olympus Labs suggests you take Elim1nate with meals, one capsule with each meal. Note that this means 3-4 capsules per day total. If you’re the kind of person who eats six meals a day, space your 3 or 4 capsules out and try to hit your biggest meals with it.

Conclusion: A Simple and Effective Two-Hit Punch

Elim1nate is a tag-team product that shows how a formula can be simple, solid, and novel. Both herbs work off of each other to inhibit aromatase in order to help lower serum estrogen levels. Luteolin and pine bark also both improve several general health parameters, improved weight loss being just one example.

Just like the one we recently blogged about (Superior Protein), Elim1nate is an interesting product. The research on luteolin alone really got us interesting, and this could definitely be for more than just AI use! At this point, it’s difficult to surprise a website dedicated to supplements and ingredients, yet Olympus Labs nearly surprises us every time they drop a new product!

Don’t sleep on Elim1nate just because it’s a two-ingredient label — this could be a very effective supplement to stack in, but as always, if you’re on prohormones or harsh anabolics/androgens, there’s only one way to find out: with before and after blood tests!

References

1. Lu, D., Yang, L., Wang, F., & Zhang, G. (2012). Inhibitory Effect of Luteolin on Estrogen Biosynthesis in Human Ovarian Granulosa Cells by Suppression of Aromatase (CYP19). Journal of Agricultural and Food Chemistry, 60(34), 8411-8418; https://pubs.acs.org/doi/abs/10.1021/jf3022817
2. Li, F., Wong, T. Y., Lin, S., Chow, S., Cheung, W., Chan, F. L., . . . Leung, L. K. (2014). Coadministrating Luteolin Minimizes the Side Effects of the Aromatase Inhibitor Letrozole. Journal of Pharmacology and Experimental Therapeutics, 351(2), 270-277; https://jpet.aspetjournals.org/content/351/2/270
3. Balunas, M., Su, B., Brueggemeier, R., & Kinghorn, A. (2008). Natural Products as Aromatase Inhibitors. Anti-Cancer Agents in Medicinal Chemistry, 8(6), 646-682; https://www.researchgate.net/publication/23159537_Natural_Products_as_Aromatase_Inhibitors
4. Jeong, H. -., Shin, Y. G., Kim, I. -., & Pezzuto, J. M. (1999). Inhibition of aromatase activity by flavonoids. Archives of Pharmacal Research, 22(3), 309-312; https://pubmed.ncbi.nlm.nih.gov/30008062
5. Li, J., Dong, J., Ren, Y., Zhu, J., Cao, J., Zhang, J., & Pan, L. (2018). Luteolin decreases atherosclerosis in LDL receptor‑deficient mice via a mechanism including decreasing AMPK‑SIRT1 signaling in macrophages. Experimental and Therapeutic Medicine; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122446/
6. Kwon, E., Kim, S., & Choi, M. (2018). Luteolin-Enriched Artichoke Leaf Extract Alleviates the Metabolic Syndrome in Mice with High-Fat Diet-Induced Obesity. Nutrients, 10(8), 979; https://www.mdpi.com/2072-6643/10/8/979
7. Barter, P. (2005). The role of HDL-cholesterol in preventing atherosclerotic disease. European Heart Journal Supplements, 7(Suppl_F); https://academic.oup.com/eurheartjsupp/article/7/suppl_F/F4/578415
8. Yu, M., Chen, J., Lai, C., Han, C., & Ko, W. (2010). Luteolin, a non-selective competitive inhibitor of phosphodiesterases 1–5, displaced [3H]-rolipram from high-affinity rolipram binding sites and reversed xylazine/ketamine-induced anesthesia. European Journal of Pharmacology, 627(1-3), 269-275; https://www.sciencedirect.com/science/article/pii/S0014299909009224
9. Xu, B., Li, X., He, G., Hu, J., Mu, X., Tian, S., & Du, G. (2010). Luteolin promotes long-term potentiation and improves cognitive functions in chronic cerebral hypoperfused rats. European Journal of Pharmacology, 627(1-3), 99-105; https://www.sciencedirect.com/science/article/pii/S0014299909009455
10. Shiota, C., Abe, T., Kawai, N., Ohno, A., Teshima-Kondo, S., Mori, H., . . . Nikawa, T. (2015). Flavones Inhibit LPS-Induced Atrogin-1/MAFbx Expression in Mouse C2C12 Skeletal Myotubes. Journal of Nutritional Science and Vitaminology, 61(2), 188-194; https://www.jstage.jst.go.jp/article/jnsv/61/2/61_188/_article
11. Parveen, K., Ishrat, T., Malik, S., Kausar, M. A., & Siddiqui, W. A. (2012). Modulatory effects of Pycnogenol in a rat model of insulin-dependent diabetes mellitus: Biochemical, histological, and immunohistochemical evidences. Protoplasma, 250(1), 347-360; https://link.springer.com/article/10.1007%2Fs00709-012-0418-2
12. Haddad, H. M. (2015). The Inhibitory Effects of Pinus Pinaster Extract and Resveratrol on Aromatase Expression in the Eutopic Endometrium of Endometriosis Patients Using Oral Contraceptives. Gynecology and Obstetrics, 05(04); https://www.omicsonline.org/open-access/the-inhibitory-effects-of-pinus-pinaster-extract-and-resveratrol-on-aromatase-expression-in-the-eutopic-endometrium-of-endometriosis-patients-using-oral-contraceptives-2161-0932-1000285.php?aid=51935
13. Shimada, T., Kosugi, M., Tokuhara, D., Tsubata, M., Kamiya, T., Sameshima, M., . . . Aburada, M. (2011). Preventive Effect of Pine Bark Extract (Flavangenol) on Metabolic Disease in Western Diet-Loaded Tsumura Suzuki Obese Diabetes Mice. Evidence-Based Complementary and Alternative Medicine, 2011, 1-9; https://www.hindawi.com/journals/ecam/2011/185913/
14. Rohdewald, P. (2002). A review of the French maritime pine bark extract (Pycnogenol), a herbal medication with a diverse clinical pharmacology. Int. Journal of Clinical Pharmacology and Therapeutics, 40(04), 158-168; https://www.dustri.com/article_response_page.html?artId=5723&doi=10.5414/CPP40158&L=0
15. Xu, N., Zhang, L., Dong, J., Zhang, X., Chen, Y., Bao, B., & Liu, J. (2014). Low-dose diet supplement of a natural flavonoid, luteolin, ameliorates diet-induced obesity and insulin resistance in mice. Molecular Nutrition & Food Research, 58(6), 1258-1268; https://onlinelibrary.wiley.com/doi/abs/10.1002/mnfr.201300830
16. Ding, et al; “Luteolin enhances insulin sensitivity via activation of PPARΓ transcriptional activity in adipocytes”; The Journal of Nutritional Biochemistry; 21(10):941-7; November 2009; https://www.researchgate.net/publication/40442088_Luteolin_enhances_insulin_sensitivity_via_activation_of_PPARG_transcriptional_activity_in_adipocytes