MFIT CBSleep: CBD-Powered Sleep Aid by a Trusted Manufacturer

CBD (Cannabidiol) seizes hold of any new conversation involving supplement industry growth and innovation. Several companies have attached many benefits to the compound. Does it live up to the hype? And if so, what are its best benefits?

MFIT Supps CBSleep

MFIT Supps CBSleep takes 25mg high-quality hemp / CBD and adds the time-tested sleep aid, melatonin!

MFIT SUPPS, PricePlow’s 2019 Rookie of the Year supplement brand, has an edge on the competition – they’re run by the manufacturer, A&Z Pharmaceutical. This is explained in our introductory article on MFIT SUPPS, and while it’s a great thing for any product, it’s especially important for something as cutting edge as CBD, where we’re finding a lot of questionable practices and low quality ‘extracts’.

MFIT Supps joins the CBD game, but with a trusted twist

So when we see a quality manufacturer-led brand enter the CBD market, we get excited – this is finally going to be one that we can trust.

CBSleep: A simple yet effective CBD formula for nighttime use

MFIT SUPPS CBSleep is a product that is fashionably late to the party, but they’re doing it exactly as we had hoped. Capsule based sleep supplements dominate the “sleeping pill” market, and CBD is easily the most exciting ‘new’ ingredient that hopes to improve sleep parameters.

CBSleep keeps it simple here though – combining melatonin and CBD in a single tablet. Honestly, we’ve been waiting for a product like this for a long time — for mainstream consumers, this a genius bridging technique. CBD oil is often sold in an oil suspension that tells customers to ingest the product sublingually. There are many uses, but a large portion of consumers use it as a sleep aid. By providing consumers with an enteric supplementation option with a safe, known, and trusted sleep ingredient, MFIT SUPPS is ahead of the game.

And in case you’re interested before going further, they’ve also released Stress-66, which is similar, but is a CBD + Ashwagandha combination rather than the melatonin used here!

The label and details are below, but first, sign up for PricePlow’s MFIT SUPPS alerts to get notified in our upcoming giveaways:

MFIT SUPPS CBSleep - Deals and Price Drop Alerts

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On the MFIT SUPPS website, CBSleep promises to help support natural circadian cycles in order to improve the overall restorative-nature of sleep. We like that the marketing angle is not promising anything ridiculous (unlike other CBD / “Hemp” brands) — just improved sleep. Does this product live up to that claim?

MFIT CBSleep Ingredients and Science

  • Full Spectrum Microencap – 25mg of Phytocannabinoids Per Dose

    MFIT SUPPS CBSleep Ingredients

    Simple and effective for sleep. Turn off your stinkin phone, take 30 minutes before bed, and get ready to get fast asleep!

    The actual label name for CBSleeps’s CBD is FullSpectrum Microencap – 250mg Sulated European Hemp Oil Powder From Verdant Oasis Hemp Oil. While that is a mouthful to say the least, the factor that matters is the 25mg of phytocannabinoids per serving. Phytocannaboinoids are the primary pharmacologically active “heavy lifting” compounds in CBD products — so knowing the exact dose is excellent.

    Inhibition of the CBD-1 Receptor

    Mechanistically, CBD appears to act through inhibition of the cannabinoid receptor type 1 (CB1).[1,2] This opposition is why CBD products don’t get you intoxicated, and don’t damage things that THC damages (such as memory and cognition). CBD appears to interact with a receptor called TRPV1[3] — which is likely why it appears to reduce pain, as TRPV1 is associated with pain and stress response.[4,5] CBD has wide-spectrum receptor modulation, meaning it will bind to tons of things, and is why so many view it as a panacea. With those mechanisms briefly covered, we can get into the sleep research and its surrounding cofactors, such as pain and anxiety.

    Improvements in Sleep: Anxiety Reduction, Less Nightmares

    CBD Supplement Use

    A great deal of users report using CBD for sleep issues, which is why this supplement makes so much sense.[7]

    Recent research suggests that ingestion of phytocannabinoids does improve sleep parameters across a multitude of disorders.[6-9] A 2018 review demonstrates that cannabinoids may improve sleep (at least short-term) in patients with conditions like sleep apnea or PTSD.[7] It appears that phytocannabinoids may reduce nightmare occurrence, reduce day-time drowsiness, and deepen overall REM sleep.[6-9] For those that suffer from intrusive thoughts in bed (read: anxiety) — CBD brings good tidings. CBD appears to be a potent anxiolytic compound,[9] so those that can’t turn their brain off in bed may want to try it out. This benefit appears to extend to pediatric populations as well.[10]

    Reduction in the sensation of pain?

    Those with chronic pain may find benefit in CBD supplementation — as CBD may reduce the sensation of pain.[11] This could be related to improvement of sleep if it’s a factor in the loss of sleep.

    Verdant Oasis Hemp Oil CBD

    Verdant Oasis Hemp Oil / CBD is certified genuine and trusted by top-tier manufacturers like A&Z Pharmaceutical

    Keeping the THC out… but do you lose effectiveness?

    However, CBD does have caveats. Cannabis has two well-known active ingredients, CBD and THC. They appear to work better as a pair, but with that of course comes legal and practical issues. Thus, isolated CBD products may offer less efficacy than the full plant.[12] However, humans do need to function most of the time and we’ll take the slightly reduced benefit of a high-quality CBD from Verdant Oasis’ Hemp Oil over being high on THC all day long.

    Long story short, CBD makes sense in a sleep supplement. But how do you add further benefits without losing appeal? With one simple and trusted ingredient:

  • Melatonin (5mg)

    Melatonin is by far the most commonly used sleep supplement. It is also one of the most effective sleep aids and often serves a role as the standard that prescription and over-the-counter drugs themselves are compared to (and they often fail in comparison).

    Melatonin Benefits

    Melatonin supplementation improves QOS (quality of sleep) and has a relatively high response rate, even at low doses.

    Melatonin is actually a hormone produced by the body and released in response to optical cues. Melatonin is likely critically important in maintaining circadian rhythms — you can think of circadian rhythms as the endocrine system’s task manager — it tells the body what happens when.

    Melatonin supplementation appears to significantly reduce how long it takes to fall asleep and even the quality of sleep.[13-14] It’s non-addictive, and is also incredible in combating jet-lag.[15] 5mg is actually a good dose — we’ve seen anywhere from 0.5mg to safe doses in the hundreds of milligrams in research! Dosing is often very personal, but with 3mg being the standard, this is slightly stronger than most melatonin supplements.

    Other “Side Benefits” in line with CBD!

    In line with what a lot of CBD users enjoy, there are general neuroprotection benefits from melatonin,[16] and it may even have an anti-cancer streak to it.[17] Since CBD also has neuroprotection benefits,[18] this match makes a ton of sense!

    It’s important to consider that some of the benefits reported from melatonin use (such as improved mood[19]) may actually be from improvements in sleep itself… but it ultimately doesn’t matter — results are results!

    In a world where we sleep a staggeringly small amount anymore, when it’s time to shut the phone off, it’s time to take the melatonin. Blue light off, sleep hormones on!

CBSleep Dosage

Take one tablet 30 minutes before bed.

Conclusion on CBSleep: It almost makes too much sense

MFIT CBSleep is a promising product that puts a super simple, but super effective spin on CBD. It’s so often used as a sleep aid, so why not use it with the most trusted sleep aid ingredient, and nothing more? We’ve seen “kitchen sink” supplements in the sleep market, but given how new CBD is, we think it’s a very smart play to use it with as few confounds or conflicting herbs as possible. Making a dual-ingredient formula is an extremely wise play.

CBSleep

Fire yourself up with MFIT SUPPS HAVOC, and bring yourself back down with CBSleep!

This is our first time seeing Verdant Oasis Hemp Oil in a sleep supplement, and that excites us because this is one of the most highly-trusted hemp oils on the market, used by other brands with impeccable quality standards. With MFIT SUPPS run at A&Z Pharmaceutical, they can take no risk in allowing a “dirty” CBD to hit their manufacturing line and tablet presses. This is why we’re excited to see them go with one of — if not the — best Hemp extracts in the world.

Ultimately, with this profile, we’re very confident that it may improve sleep, but we cannot say for certain that it does improve sleep. Even if CBD doesn’t work for you in that capacity, the melatonin is still there to bring up the rear. But at the end of the day (both literally and figuratively), it’s up to you to turn off the phone, read a few pages in a real book, and go to bed on time.

If you’ve been itching to try CBD as a sleep aid, this one is a no-brainer — check out CBSleep. But if you’re looking for CBD as a stress reliever, MFIT SUPPS also has Stress-66… stay tuned!

MFIT SUPPS CBSleep - Deals and Price Drop Alerts

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Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.

Posts are sponsored in part by the retailers and/or brands listed on this page.

About the Author: Mike Roberto

Mike Roberto

Mike Roberto is a research scientist and water sports athlete who founded PricePlow. He is an n=1 diet experimenter with extensive experience in supplementation and dietary modification, whose personal expertise stems from several experiments done on himself while sharing lab tests.

Mike's goal is to bridge the gap between nutritional research scientists and non-academics who seek to better their health in a system that has catastrophically failed the public.

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References

  1. Thomas, A et al; “Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro”; British journal of pharmacology vol. 150,5 (2007): 613-23; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189767/
  2. Aso, E, et al; “Adenosine A2A-Cannabinoid CB1 Receptor Heteromers in the Hippocampus: Cannabidiol Blunts Δ9-Tetrahydrocannabinol-Induced Cognitive Impairment”; Molecular Neurobiology; 56(8):5382-5391; August 2019; https://www.ncbi.nlm.nih.gov/pubmed/30610611
  3. Iannotti, F, et al; “Nonpsychotropic plant cannabinoids, cannabidivarin (CBDV) and cannabidiol (CBD), activate and desensitize transient receptor potential vanilloid 1 (TRPV1) channels in vitro: potential for the treatment of neuronal hyperexcitability”; ACS Chemical Neuroscience; 5(11):1131-41; Nov. 19, 2014; https://www.ncbi.nlm.nih.gov/pubmed/25029033
  4. Jara-Oseguera, A., Simon, S. and Rosenbaum, T. (2008). TRPV1: On the Road to Pain Relief. Current Molecular Pharmacology, 1(3), pp.255-269; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2802457/
  5. Ho, Karen W et al; “TRPV1: a stress response protein in the central nervous system”; American Journal of Neurodegenerative Disease; vol. 1,1 (2012): 1-14; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560445/
  6. Babson, K., Sottile, J. and Morabito, D. (2017). Cannabis, Cannabinoids, and Sleep: a Review of the Literature. Current Psychiatry Reports, 19(4); https://www.ncbi.nlm.nih.gov/pubmed/28349316
  7. Corroon, J. and Phillips, J. (2018). A Cross-Sectional Study of Cannabidiol Users. Cannabis and Cannabinoid Research, 3(1), pp.152-161; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043845/
  8. Pertwee, R. (2014). Handbook of cannabis. New York: Oxford University Press; https://www.oxfordscholarship.com/view/10.1093/acprof:oso/9780199662685.001.0001/acprof-9780199662685-chapter-29
  9. Shannon, S. (2019). Cannabidiol in Anxiety and Sleep: A Large Case Series. The Permanente Journal; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326553/
  10. Effectiveness of Cannabidiol Oil for Pediatric Anxiety and Insomnia as Part of Posttraumatic Stress Disorder: A Case Report. (2019). The Permanente Journal; https://www.thepermanentejournal.org/issues/search/results/49-the-permanente-journal/case-studies/6244-effectiveness-of-cannabidiol-oil-for-pediatric-anxiety-and-insomnia-as-part-of-posttraumatic-stress-disorder-a-case-report.html
  11. Russo, E. (2008). Cannabinoids in the management of difficult to treat pain. Therapeutics and Clinical Risk Management, Volume 4, pp.245-259; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2503660/
  12. Russo, E. (2019). The Case for the Entourage Effect and Conventional Breeding of Clinical Cannabis: No “Strain,” No Gain. Frontiers in Plant Science, 9; https://www.ncbi.nlm.nih.gov/pubmed/30687364
  13. Lemoine, Patrick, et al; “Prolonged-Release Melatonin Improves Sleep Quality and Morning Alertness in Insomnia Patients Aged 55 Years and Older and Has No Withdrawal Effects.”; Journal of Sleep Research; U.S. National Library of Medicine; Dec. 2007; https://www.ncbi.nlm.nih.gov/pubmed/18036082
  14. Alstadhaug, Karl B, et al; “Prophylaxis of Migraine with Melatonin: a Randomized Controlled Trial.”; Neurology; U.S. National Library of Medicine; 26 Oct. 2010; https://www.ncbi.nlm.nih.gov/pubmed/20975054
  15. Herxheimer, A, Petrie, K; “Melatonin for the prevention and treatment of jet lag”; The Cochrane Database of Systematic Reviews; (2):CD001520; 2002; https://www.ncbi.nlm.nih.gov/pubmed/12076414
  16. Wang, Z, et al; “Role of melatonin in Alzheimer-like neurodegeneration”; Acta Pharmacoligica Sinica; 27(1):41-9; January 2006; https://www.ncbi.nlm.nih.gov/pubmed/16364209
  17. Mills, E, et al; “Melatonin in the treatment of cancer: a systematic review of randomized controlled trials and meta-analysis”; Journal of Pineal Research; 39(4):360-6; November 2005; https://www.ncbi.nlm.nih.gov/pubmed/16207291
  18. Hampson, Aidan J, et al; “Cannabinoids as antioxidants and neuroprotectants”; http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=6630507.PN.&OS=PN/6630507&RS=PN/6630507
  19. Dollins, A B et al; “Effect of inducing nocturnal serum melatonin concentrations in daytime on sleep, mood, body temperature, and performance”; Proceedings of the National Academy of Sciences of the United States of America vol. 91,5 (1994): 1824-8; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC43256/

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