Magnum Fixation: The Fix for Painful Joints and Sore Muscles

Magnum Fixation

Fixation is the latest innovation from Magnum Nutraceuticals that supports joint and muscle recovery.

It’s been awhile since we’ve covered any new developments from Magnum Nutraceuticals up in Canada. Last we saw of the brand, they had just released Magnum After Burner — a unique take on the traditional stim-free / before-bedtime fat burner category.

Well, things are turning and burning once again at Magnum HQ and the brand has just launched Fixation — a clinically dosed joint support formula that aims to be the ultimate fix for your joint woes.

This one has a great mix of herbal anti-inflammatories like CurcuWIN curcumin and cissus, but also one of our favorite joint-repair compounds in MSM – and more – all in solid doses! Even better, CurcuWin might be the best curcumin absorption system we’ve seen yet, since it’s using two methods to improve bioavailability.

We’ve got more info just below, but first, take a moment to check the best deal and sign up for alerts from PricePlow:

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Fixation Ingredients

Fixation uses some of the true power players in the joint help realm (in proper doses), along with a couple interesting additions that all add up to a rather fine and effective formula.

Note: Doses listed below are based on 1 daily serving (i.e. 4 capsules).

  • MSM (2,000mg)

    Magnum Fixation Ingredients

    Fixation contains 6 well dosed ingredients to enhance joint function and combat inflammation.

    MSM is a “must have” ingredient for quality joint formulas. This sulfur-containing molecule is naturally-occurring in nature and the human body. MSM supplies an incredibly bioavailable form of sulfur that’s used for protein synthesis, connective tissue formation, and nutrient absorption.[1]

    We’ve covered this ingredient rather thoroughly before in our MSM Supplement guide, so go there if you want the whole story.

    The cliff notes version is basically that MSM speeds recovery from injury[2], improves mobility[3,4], and reduces inflammation.[5] Most research shows you need at least 3g/day MSM to see these benefits — which you’ll get following Magnum’s recommended 2 servings per day of Fixation!

  • Cissus Quadrangularis 20:1 Extract (300mg)

    Magnum Fixation Fix It

    Achy joints? Fix it with Magnum Fixation.

    A relative of grapes, Cissus quadrangularis is a medicinal plant traditionally used in Ayurveda to heal broken bones, banged up tendons, and injured ligaments. Cissus is loaded with several compounds which have been shown to mobilize blast cells to injured areas of the body.[6] These compounds enhance retention of mucopolysaccharides, key minerals including calcium and phosphorous, and most importantly collagen, which supply the necessary “building blocks” for tissue repair.

    Additionally, Cissus exerts some powerful anti-inflammatory effects which help reduce swelling, aches, and pains from a lifetime of heavy lifting. Plus, it also inhibits the release of cytokines and neutrophils (varieties of white blood cells) that are released to damaged areas of the body, which can contribute to inflammation.[7]

    Again, you’re looking to need a 3g dose / day to see benefits from Cissus. However, the strength of this extract we’re interested in – we haven’t seen one this strong before. Magnum uses an incredibly unique Cissus extract that’s standardized for 5.0% at a 20:1 ratio, which they state is equivalent to 6000mg Cissus and 300mg ketosterones daily. So, theoretically, you should be getting double the daily necessary dose…

  • CurcuWIN™ 12:1 Extract (200mg)

    CurcuWIN™ is an enhanced absorption form of curcumin extract that delivers 20% curcuminoids in a 12:1 extract that’s equivalent to 600mg Curcuminoids daily.

    CurcuWin

    CurcuWin claims a far better bioavailability of curcuminoids thanks to their UltraSOL Delivery System

    For those of you not familiar with Curcumin, it’s the active ingredient in Turmeric, a spice commonly used in Indian cooking. Curcumin is a powerful anti-inflammatory compound that helps fight both acute and chronic inflammation in the body through inhibition of Cytokine production[8,9] and down-regulation of COX-2 activity (similar to Ibuprofen).[8]

    This is an Ayurvedic supplement that has so many health benefits – and is far too often ignored by athletes even though it’s a fantastic anti-inflammatory. Don’t sleep on this one just because it’s a yogi-favorite.

    If you want even more info on Curcumin, be sure to check out our mega-post titled Curcumin Supplements for Joint Pain: A “Curry” a Day?

    About CurcuWin specifically

    This form of Curcumin uses a proprietary delivery system made by OmniActive Health Technologies known as UltraSOL, and it seems highly similar to Hi-Tech Pharma’s Cyclosome process, in that it’s using two forms of absorption technologies together:

    Supplement Delivery System

    A cyclodextrin (in green) encapsulating a hydrophobic molecule (in blue), making it better absorbed in aqueous environments. Image courtesy Wikimedia.

    1. a liposome to encapsulate the curcuminoid in a fatty acid (typically either phosphatidylcholine or phosphatidylserine), but also
    2. adds a cyclodextrin so that it’s more hydrophillic and better absorbed in water, rather than being hydrophobic and repelling water. See the image.

    We haven’t seen this process used with curcumin in a sports nutrition setting yet, so it’s great to see innovation spreading throughout the industry and getting into our joints.

  • Rosemary 10:1 Extract (150mg)

    A hearty, wintery herb that’s best used alongside potatoes, Rosemary also improves joint pain due to two compounds present in its leaves — Carnosol and Carnosic acid. These two compounds act as powerful antioxidants and anti-inflammatories which have been shown to reduce swelling of joints, muscles, and ligaments.[10,11]

    This marks a first for us seeing Rosemary in a joint formula. Maybe Magnum is onto something with this herb?

  • Boswellia Serrata 15:1 Extract (144mg)

    Magnum Fixation Joints

    Put the brakes on joint pain with the help of Magnum Fixation.

    Boswellia serrata is yet another medicinal plant with a rich history of use in ancient medicines. Boswellia is loaded with a number of powerful bioactive compounds, Boswellic Acid in particular.

    Clinical trials show boswellia is rather effective for improving joint function and reducing stiffness.[12,13] Additionally, it inhibits MMP-3 activity, which defends against collagen breakdown.[14]

    There’s more to Boswellia than joint health though, it’s also used as a treatment for Ulcerative colitis (UC), Crohn’s disease, and even slowing tumor growth.[15,16]

  • Ginger 4:1 Extract (140mg)

    Lastly, we have another popular rhizome used in Asian and Indian cooking, Ginger. Magnum includes a 4:1 extract that’s equivalent to 560mg of a 1:1 ginger extract.

    Ginger is loaded with all sorts of bioactive compounds including gingerols, zingerone, shogaols, and other volatile oils, all of which exert a variety of reactions and antioxidant actions in the body. When applied to joints, ginger extracts have been shown reduce pain and stiffness in knee joints of patients with osteoarthritis by 40%![17]

Interesting tidbit: two of these ingredients, cissus and ginger, also have fat-burning capabilities to them!![18,19] While that’s obviously not what this is marketed to, could a dash of weight loss be a “beneficial side effect” of Fixation here? We absolutely think it’s possible!

Dosing

Magnum Girls

Fixation protects one of your most valuable assest — your joints. Need evidence? Just look to Magnum’s impressive line of female athletes.

Take 2 capsules twice daily with food, preferably. For optimal absorption and effectiveness, Magnum recommends that the meals contain some form of fat.

Takeaway

HardMagnum’s been quiet, but they’re not dead. They still have the strongest glucose disposal agent we’ve ever taken in the Magnum MIMIC, and are still riding high on sales of their Quattro protein powder. Now they have something good to fix those joints up, and it’s a great mix of the “herbal” side with the physical compound side (MSM).

While analyzing endless carbon copy pre workouts can get a bit tiring every now and then, one type of supplement we never get enough of are joint support formulas — especially well dosed ones such as Fixation.

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References

  1. Brosnan JT, Brosnan ME. The Sulfur-Containing Amino Acids: An Overview. J Nutr. 2006;136(6):1636S-1640. http://jn.nutrition.org/cgi/content/long/136/6/1636S
  2. Peel S. et al. The Effects of MSM Supplementation on Knee Kinetics during Running, Muscle Strength, and Muscle Soreness following Eccentric Exercise- Induced Quadriceps Damage. Presented at American Society for Biomechanics Conference Aug, 2015. https://www.docdroid.net/a3czJbh/peel-2015.pdf.html
  3. Pagonis TA, Givissis PK, Kritis AC, Christodoulou AC. The Effect of Methylsulfonylmethane on Osteoarthritic Large Joints and Mobility. International Journal of Orthopaedics 2014; 1(1): 19-24. http://www.ghrnet.org/index.php/ijo/article/view/745
  4. Kim et al. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. OsteoArthritis and Cartilage 2006, 14:286-294. http://www.oarsijournal.com/article/S1063-4584(05)00285-2/fulltext (Full PDF available at http://www.ghrnet.org/index.php/ijo/article/download/745/857
  5. Usha, P.R. & Naidu, M.U.R. Randomised, Double-Blind, Parallel, Placebo-Controlled Study of Oral Glucosamine, Methylsulfonylmethane and their Combination in Osteoarthritis. Clin. Drug Investig. (2004) 24: 353. doi:10.2165/00044011-200424060-00005. http://docdro.id/84iXcMd
  6. Udupa, KN, and Guru Charan Prasad. “Further Studies On The Effect Of Cissus Quadrangularis In Accelerating Fracture Healing.” The Indian journal of medical research 52 (1964): 26-35.
  7. Jainu, Mallika, and Chennam Srinivasulu Shyamala Devi. “Attenuation of neutrophil infiltration and proinflammatory cytokines by Cissus quadrangularis: a possible prevention against gastric ulcerogenesis.” Journal of herbal pharmacotherapy 5.3 (2005): 33-42.
  8. Jurenka, J; Anti-inflammatory Properties of Curcumin, a Major Constituent of Curcuma longa: A Review of Preclinical and Clinical Research; Alt Med Rev; 2009
  9. Kumar, A., Takada, Y., Borief, A., Aggarwa, B.; Nuclear factor KappaB: its role in health and disease; J Mol, Med; 2004
  10. Johnson JJ. Carnosol: A promising anti-cancer and anti-inflammatory agent. Cancer letters. 2011;305(1):1-7. doi:10.1016/j.canlet.2011.02.005. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070765/
  11. Arranz, E., Jaime, L., García-Risco, M. R., Fornari, T., Reglero, G. and Santoyo, S. (2015), Anti-inflammatory activity of rosemary extracts obtained by supercritical carbon dioxide enriched in carnosic acid and carnosol. Int J Food Sci Technol, 50: 674–681. doi:10.1111/ijfs.12656. http://onlinelibrary.wiley.com/doi/10.1111/ijfs.12656/abstract
  12. Sengupta K, et al; Comparative efficacy and tolerability of 5-Loxin and Aflapin Against osteoarthritis of the knee: a double blind, randomized, placebo controlled clinical study. Int J Med Sci. (2010)
  13. Sengupta K, et al; A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin for treatment of osteoarthritis of the knee. Arthritis Res Ther. (2008)
  14. http://www.ncbi.nlm.nih.gov/pubmed/21479939
  15. http://www.ncbi.nlm.nih.gov/pubmed/24647155
  16. http://www.ncbi.nlm.nih.gov/pubmed/23500016
  17. Altman RD, Marcussen KC. Effects of a ginger extract on knee pain in patients with osteoarthritis. Arthritis Rheum. 2001;44(11):2531-2538. https://www.ncbi.nlm.nih.gov/pubmed/11710709.
  18. Oben J, Kuate D, Agbor G, Momo C, Talla X. The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome. Lipids in Health and Disease. 2006;5:24. doi:10.1186/1476-511X-5-24. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1570348/
  19. Mansour MS, Ni Y-M, Roberts AL, Kelleman M, RoyChoudhury A, St-Onge M-P. Ginger consumption enhances the thermic effect of food and promotes feelings of satiety without affecting metabolic and hormonal parameters in overweight men: A pilot study. Metabolism: clinical and experimental. 2012;61(10):1347-1352. doi:10.1016/j.metabol.2012.03.016. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408800/
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