Glaxon Slyce Gets A Radical Fat Burning Facelift! Introducing Slyce V2

Long-time readers of this blog will definitely be familiar with Glaxon, a radical outfit of die-hard nutritional innovators who always send us something new.

Glaxon Slyce V2: Get ready for something new!

Glaxon Slyce has been updated in late 2021, and there are some monumentally unique ingredients!

Today we’re excited to announce that Glaxon is revamping their popular fat-burning supplement, Slyce. We’re comfortable calling this change a fairly dramatic one: a lot of mainstay fat-burning ingredients, such as green tea extract, are being eliminated, and some completely new and far-out ingredients have been added.

In this industry, it’s easy to feel like we’re dealing with the same formulas over and over again — not so with Glaxon. A few of the ingredients we’re covering today are ones we’d never even heard of before!

What we appreciate most about this supplement is not just that it’s innovative, but also that it’s smart. Glaxon really pulled out all the stops when they re-formulated this one, and came up with solutions to problems that most manufacturers never even think about.

The result is a versatile fat-burning supplement that will support you on a calorie cut, or maybe even just help recomposition. Let’s take a look at it, but first check the coupon-powered prices brought to you by PricePlow:

Glaxon Slyce Ingredients

Get ready for something different — as always with Glaxon, there’s some unique new ingredients inside Slyce!

Here’s what you get in a single two capsule serving of Slyce V2 Stimulant Fat Burner from Glaxon:

• Niacin (Nicotinic Acid) – 20 mg

  Kicking things off with a classic, niacin is one of the most basic and effective fat loss aids there is. Niacin increases your body’s levels of adiponectin,^[1] a hormone that exerts a wide range of pro-metabolic effects. Adiponectin improves insulin sensitivity, and its levels decrease in obese people.^[2] Adiponectin also increases the body’s expenditure of energy by activing AMP-actived protein kinase (AMPK),^[3] one of the metabolic “master switches” that is centrally implicated in almost any fat loss strategy.

  Niacin itself also decreases inflammation in body fat,^[1] a type of inflammation that has been repeatedly linked to metabolic disease.^[4]

• Caffeine Anhydrous – 250 mg

  Caffeine is one of the most studied compounds in sports nutrition because of its incredible properties as an ergogenic aid. It’s capable of crossing the blood-brain barrier, which allows it to block adenosine and phosphodiesterase receptors in the brain,^[5] decreasing fatigue and increasing neural activity.^[5] Caffeine also oxidizes fat, making more energy available to the body during workouts. This is especially good for people who are on ketogenic or low-carb diets, and adapted to using fat as their primary energy source.^[6-8]

  

  Get ready to Slyce through fat stores and burn it away!

  The anhydrous part means this caffeine has been dehydrated, which increases its rate of absorption in the body. Caffeine anhydrous is typically preferred to other forms of caffeine in high-performance settings because it is fast-acting.

• L-Tyrosine – 250 mg

  When it comes to supporting fat loss, tyrosine has one big benefit: it is a precursor to the thyroid hormones thyroxine (T4) and triiodothyronine (T3).^[9] For this reason, you definitely do not want to be deficient in tyrosine, because low tyrosine levels have been linked to disturbances in thyroid function.^[10]

  

  Long story short: No iodine or tyrosine, no thyroid hormone synthesis. Get enough iodine and tyrosine in!!

  If you’re trying to lose fat, a slow thyroid is the last thing you want, because reduced thyroid function has been linked to a lower basal metabolic rate, which is going to make your fat loss efforts that much harder.^[11] At the same time, cutting calories will in itself put stress on the thyroid: in obese women, a very low calorie diet can reduce levels of active thyroid hormone by as much as 66%.^[12]

  So, it makes sense that tyrosine, the thyroid hormone precursor, is in this supplement. Anyone who’s cutting calories to lose weight will want to give their thyroid as much extra support as possible.

• Electric Daisy (Acmella oleracea) Extract – 100 mg

  Glaxon is known for using unique and innovative ingredients, and this ingredient is a perfect example of that. Most of you have probably never heard of this one — even we hadn’t.

  

  Say hello to the Electric Daisy

  Extract from the Acmella oleracea (Electric Daisy) plant contains a compound called spilanthol. It’s cutting edge, and there’s not much research about it, but the research that does exist is very promising: in rats, spilanthol has been shown to activate AMP-activated protein kinase (AMPK),^[13] one of the metabolic “master switches” that is targeted by so many of the awesome fat loss compounds that PricePlow writes about on a regular basis. Other examples of AMPK activators include berberine, cinnamon, aerobic exercise, and some well-known prescription drugs, as well as many other battle-tested heavy-hitters involved with improving human metabolic health.

  Besides activating AMPK, spilanthol was shown to suppress the expression of genes that promote fat gain,^[13] and increase the rate of lipolysis (fat burning) directly.^[13] It was also shown to prevent the chronic, low-grade inflammation that is linked to the development of metabolic disease.^[13]

  Taking all of this together, it’s no surprise that spilanthol significantly reduced weight gain in rats that were fed a high-fat diet.^[13]

  Note: to learn more about the AMPK angle, read about berberine in our article on the Glaxon Xerion glucose disposal agent!

• English Ivy (Hedera helix) [leaf] Extract – 100 mg

  

  Hedera helix, also known as “English ivy”

  It isn’t common knowledge that English Ivy is rich in saponins and flavanoids,^[14] two classes of phytochemicals that have been linked to improved fat metabolism^[15] and body composition.^[16]

  When tested in rats, Hedera helix extract was shown to protect against diabetes,^[17] by lowering HbA1C and blood glucose levels. The effect was so pronounced that researchers were able to observe differences in the organ tissue structure of rats treated with Hedera, compared to rats that weren’t.

• Phenylcapsaicin (1% as aXivite) – 100 mg

  

  Using both tried-and-true and novel ingredients, Glaxon Xerion is an incredibly unique play for longevity-boosting insulin-sensitivity. Enjoy your carbs with this one!

  Phenylcapsaicin is a synthetic analogue of capsaicin, an active component of chili peppers that produces the burning sensation you feel in your mouth after eating them. Capsaicin also has some intriguing potential benefits when it comes to metabolic health. In obese mice, capsaicin improves insulin sensitivity^[18] and reduces fatty liver,^[18] as well as lowers fasting glucose^[18] and insulin.^[18]

  Capsaicin was also shown to reduce the levels of TNFα, IL-6, and MCP-1 in the liver — crucial for metabolic health, since these inflammatory cytokines have been linked to metabolic disease.^[18]

  The advantage of using phenylcapsaicin (aXivite) is that it’s claimed to be more stable and up to eight times more bioavailable than ordinary capsaicin, although we need research to cite on that and will update this post when it’s available.

• Sichuan Peppercorn (Zanthoxylum) [seed husk] powder – 100 mg

  Commonly used in Chinese cuisine, Sichuan pepper has been shown to inhibit fatty acid synthase (FAS), the multi-enzyme system that’s responsible for synthesizing human body fat.^[19] Increased expression of FAS has been linked to obesity and type 2 diabetes,^[20] so anyone who’s trying to prevent or correct those conditions could potentially benefit from using Sichuan pepper.

  

  Sichuan peppercorns

  Sichuan pepper has also been shown to contain chlorogenic acid,^[21] an antioxidant with anti-obesity properties.^[22]

• Wakame (Undaria pinnatifida) Extract – Std. to 25% Fucoxanthin

  Fucoxanthin improves the metabolism of carbohydrates by upregulating a protein called glucose transporter 4 (GLUT4) in muscle tissue. Since GLUT4 is responsible for shuttling glucose into the cell from the blood, this means that the carbs you eat will be stored more in muscle, leaving less to be stored in your fat cells.^[23,24]

  Upregulating GLUT4 will help prevent fat storage, but fucoxanthin also helps eliminate fat that’s already been stored. It does this because it upregulates uncoupling protein 1 (UCP1) in white fat cells,^[25] which boosts metabolism and thus, potentially helps fat loss.^[26]

  In animals, eating high-fucoxanthin seaweeds has been shown to inhibit the growth of fat cells and to improve satiety.^[27]

• Kelp (Ascophyllum nodosum) Powder – 50 mg

  As we were saying in the section on tyrosine above, thyroid function is crucial for maintaining the metabolic rate and maximizing fat loss, and iodine is crucial for thyroid function.^[28] Kelp is one of the best whole-food sources of iodine,^[29] so it’s no surprise to see it included in this formula. Iodine deficiency can cause hypothyroidism,^[28] which will lower the metabolic rate and contribute to fat gain.^[30,31]

• Theobromine – 50 mg

  

  SLYCE

  Theobromine is an alkaloid found in cocoa. Like caffeine, theobromine inhibits the action of adenosine and phosphodiesterase, which makes you more alert and motivated.^[32] However, theobromine has a longer half-life than caffeine,^[32] which should provide a longer, smoother boost of energy. That’s perfect for people who are running a calorie deficit.

  Theobromine can potentially help weight loss by upregulating cyclic adenosine monophosphate (cAMP),^[33] which improves fat metabolism in the body.^[34]

• Alligator pepper (Afromomum melegueta) [seed] extract [as Paradoxine] – 30 mg

  The trademarked Paradoxine extract of alligator pepper, a plant also known as grains of paradise, is standardized for 6-paradol, a compound in the phenol class that turns white adipose tissue, or WAT, into brown adipose tissue, also known as BAT.

  Why does this matter? BAT uses more energy than WAT, so the more BAT you have, the higher your metabolic rate will be.^[35,36] That’s an obvious plus for anyone who’s looking to lose their spare tire.

  If you want an in-depth analysis of how Paradoxine helps us burn fat, please read our article Grains of Paradise: Fat Fighting Spice of the Goddesses.

• Evodia rutaecarpa [Fruit] extract [Std. to 98% Evodiamine] – 30 mg

  

  Evodiamine is a potent fat-fighting molecule that increases thermogenesis and prevents your body from creating additional fat cells.

  Evodiamine is an alkaloid from the Evodia rutaecarpa plant whose mechanism of action is similar to that of capsaicin,^[37] which we discussed above. In mice, evodiamine has been shown to increase thermogenesis (the burning of energy as heat) and reduce fat mass.^[38,39] In addition to keeping existing fat cells relatively empty, evodiamine may also prevent the growth of new fat cells by inhibiting preadipocyte differentiation.^[40]

• Cape Aloe (Aloe ferox) [Leaf] powder – 10 mg

  We all intuitively know that bowel movements are stimulated by eating. This process, known to science as the “gastrocolic reflex,” is the body’s way of making room for new food by eliminating what’s already been eaten. The gastrocolic reflex works by increasing your intestinal motility — the mechanical ability of your intestines to move food out of the body.^[41]

  

  Want to burn even more fat, without adding any more stimulants? Look into Glaxon Thermal!

  Because the elimination of old food is triggered by the ingestion of new food, one risk of dieting by cutting calories is that you might become constipated from an absence of gastrocolic reflex and a lack of intestinal motility. This risk can be especially acute if you combine a calorie cut with intermittent fasting, since both the volume and frequency of your eating have declined.

  Aloe plants have the ability to increase intestinal motility when consumed,^[42] which is why Glaxon included it here, where it can provide gastrointestinal support to anyone who’s dieting and possibly help prevent constipation.

• Kanna (Sceletium tortuosum) [Aerial Parts] Extract (As Zembrin) – 10 mg

  Zembrin is a patented extract of the Sceletium tortuosum plant, also known as kanna. Native to South Africa, kanna has been in human use since prehistoric hunter-gatherer cultures began chewing its leaves to fight fatigue and improve mood.^[43] People have also been known to chew the plant before entering into high-stress situations.^[44]

  

  Zembrin offers everything you want in a nootropic…better focus, mood, and cognition, all with less stress and anxiety. Image courtesy Zembrin

  Kanna has these effects because it’s a phosphodiesterase-4 inhibitor, meaning that it upregulates cyclic adenosine monophosphate (cAMP),^[44] a secondary messenger that is required fir metabolizing glucose and fat. Put simply, without enough cAMP, you won’t have enough energy. Caffeine also increases cAMP expression,^[43,45] so that should give you an idea of what to expect from kanna.

  Upregulation of cAMP is linked to increased thermogenesis and anti-obesogenic effects.^[43,45,46]

• BioPerine (Black Pepper (fruit) Extract std. to 95% Piperine) – 5mg

  There’s a very good reason that BioPerine shows up so frequently in premium supplements such as this one. By inhibiting stomach enzymes that break down supplement ingredients, it can dramatically increase the bioavailability of many of them.

  But BioPerine has plenty of beneficial effects in its own right: the piperine component of the extract upregulates GLUT4,^[47] the same transporter we discussed above in the fucoxanthin section. In mice, BioPerine has been shown to decrease insulin resistance and fatty liver,^[48] and has powerful antioxidant properties.^[49]

  Piperine is great for capsule supplements

  It’s always nice to see supplement manufacturers include BioPerine in capsule formulas, because although there are tons of benefits to including even very small doses of this extract, it’s generally avoided in powders because of the spicy taste.

  Since taste isn’t a factor in swallowing capsules, here you can get the upsides of BioPerine with none of the downside.

• Rauwolfia (Rauwolfia vomitoria) [Leaf] Extract (Std. for 90% Rauwolscine) – 0.5 mg

  Extracts from Rauwolfia are usually standardized for rauwolscine. Known as “alpha yohimbine,” these extracts are generally thought of as a stand-in for yohimbine, but stronger. So what is yohimbine?

  Yohimbine, which can also be derived from the Rauwolfia plant, is an alpha-2 antagonist, which means that it binds to the receptors for adrenaline and noradrenaline and mimics the action of those hormones. By this means, yohimbine suppresses appetite,^[50] aids weight loss,^[51] and improves focus.^[52] Rauwolscine has the same mechanism of action — it has been shown to both prevent fat storage and help supply the body with energy.^[53]

  

  The Glaxon Slyce Stack

  Individual reactions to rauwolscine vary: most have no problem, but a few might get jittery. If you can tolerate rauwolscine, be sure to take advantage of the benefits it has on metabolism and fat loss.^[54]

Conclusion

If you’re tired of the same old run-of-the-mill fat burner products, and looking for something new, definitely do not sleep on Slyce V2 from Glaxon.

For those of you who are already loyal Glaxon customers, be aware that Slyce is intended to stack incredibly well with Glaxon’s previous releases Thermal, their non-stimulant fat-burner supplement, and Xerion, their nutrient-partitioning supplement that’s designed to help control blood glucose and insulin levels.

We do not recommend stacking Slyce with the Specimen pre-workout supplement from Glaxon, because that would give you a combined total of 550 milligrams of caffeine — way too much for the vast majority of people to take in a single serving. Instead, consider stacking Slyce with Glaxon’s non-stimulant pre-workouts, Plasm Caps (available in capsules) or Plasm Surge (available as a powder).

Now you are ready to Slyce the fat away!